Taurine has long been a staple in energy drinks and pre-workout formulas, but it’s recently landed in hot water. A new Nature study set off alarms, suggesting this common compound could accelerate the progression of leukemia. Suddenly, a molecule once known for cellular protection and performance is being framed as a red flag for cancer. So, if you’re wondering whether there’s more to the story, you’re right. There is.
Taurine is a naturally occurring semi-essential amino acid found in meat, fish, and dairy. It’s synthesized in the liver and is most concentrated in the heart, brain, retina, and nerves. Studies have shown it to play essential roles in bile acid formation, regulating calcium signaling, stabilizing cell membranes, supporting cardiovascular function, and modulating the immune system.
While it’s not a stimulant like caffeine, it’s often lumped into the same category due to its heavy use in energy drinks. Instead, taurine works more behind the scenes to support cellular health and boost antioxidant activity.
Danijela/Adobe Stock
In this new study on mice and human cellular cultures, researchers found a link between taurine and a faster progression of leukemia. It appeared to support the mitochondria giving cancer cells the fuel they need to grow under stress.
However, it’s important to keep in mind that the findings may prove that it promotes leukemia in a specific biological context: the bone marrow tumor microenvironment. The researchers aren’t claiming taurine causes cancer in healthy people. They’re saying that in the presence of leukemia, taurine appears to act as a growth-supporting factor in mice and cellular cultures in a lab.
They discovered that certain cells, called osteolineage cells, in the bone marrow (the same cells that help build bone) produce taurine, and that this may act as fuel for leukemia cells.
When scientists inhibited taurine production in these bone-forming cells, by deleting a gene called CDO1, nearby leukemia cells became significantly less viable and formed fewer colonies. But once they added it back, the cancer cells bounced back too. When they supplemented mice with it, it accelerated leukemia progression and tripled the death rate in mice with normal immune systems.
They saw the same effect using human bone marrow cells and leukemia samples from real patients.
These results suggest that in the presence of leukemia, taurine may act as an unwitting accomplice, helping cancer cells thrive by stabilizing their energy production. It’s not that taurine causes leukemia, but once the disease is present, it may help the cancer cells survive longer.
Still, this is a very specific scenario, in leukemia, in bone marrow, in mice and co-cultured cells. The findings don’t automatically mean taurine is dangerous to healthy individuals. But they do open the door to more questions.
Could certain cancers exploit nutrients that otherwise support healthy metabolism? Could a “good” molecule turn “bad” in the wrong environment?
Science continues to evolve, so answers change over time. That’s why this may be a prompt to start asking more questions.
Юлия Сергеева/Adobe Stock
Here’s where it gets interesting: taurine isn’t new to cancer research. Multiple studies suggest it might inhibit cancer growth in certain contexts. A randomized controlled trial published in the Journal of Cancer Research and Therapeutics highlighted that taurine supplements helped reduce the harmful side effects of chemotherapy in young adults being treated for acute lymphoblastic leukemia. Other studies have shown taurine’s ability to trigger apoptosis (cell death) in various cancer cells, including breast cancer. It also reduces oxidative stress and modulates inflammation, both important factors in cancer prevention.
How can taurine be both cancer-feeder and anticancer? Because biology is context-dependent. Taurine may protect healthy cells and promote recovery in stressed environments. But in the presence of malignant, fast-dividing cells, its same supportive properties could enhance cancer cell survival.
In other words: Is it good or bad? The better question might be, “Good or bad for whom… and under what conditions?”
Taurine has been found to play vital roles in cardiovascular function, brain health, and central nervous system health. Some studies even suggest taurine deficiency may be a driver of aging.
But if you’re undergoing treatment for cancer, especially leukemia, it’s worth asking your oncologist before supplementing.
Continue reading...
What Is Taurine?
Taurine is a naturally occurring semi-essential amino acid found in meat, fish, and dairy. It’s synthesized in the liver and is most concentrated in the heart, brain, retina, and nerves. Studies have shown it to play essential roles in bile acid formation, regulating calcium signaling, stabilizing cell membranes, supporting cardiovascular function, and modulating the immune system.
While it’s not a stimulant like caffeine, it’s often lumped into the same category due to its heavy use in energy drinks. Instead, taurine works more behind the scenes to support cellular health and boost antioxidant activity.
Danijela/Adobe Stock
The Study Stirring Controversy
In this new study on mice and human cellular cultures, researchers found a link between taurine and a faster progression of leukemia. It appeared to support the mitochondria giving cancer cells the fuel they need to grow under stress.
However, it’s important to keep in mind that the findings may prove that it promotes leukemia in a specific biological context: the bone marrow tumor microenvironment. The researchers aren’t claiming taurine causes cancer in healthy people. They’re saying that in the presence of leukemia, taurine appears to act as a growth-supporting factor in mice and cellular cultures in a lab.
They discovered that certain cells, called osteolineage cells, in the bone marrow (the same cells that help build bone) produce taurine, and that this may act as fuel for leukemia cells.
When scientists inhibited taurine production in these bone-forming cells, by deleting a gene called CDO1, nearby leukemia cells became significantly less viable and formed fewer colonies. But once they added it back, the cancer cells bounced back too. When they supplemented mice with it, it accelerated leukemia progression and tripled the death rate in mice with normal immune systems.
They saw the same effect using human bone marrow cells and leukemia samples from real patients.
These results suggest that in the presence of leukemia, taurine may act as an unwitting accomplice, helping cancer cells thrive by stabilizing their energy production. It’s not that taurine causes leukemia, but once the disease is present, it may help the cancer cells survive longer.
Still, this is a very specific scenario, in leukemia, in bone marrow, in mice and co-cultured cells. The findings don’t automatically mean taurine is dangerous to healthy individuals. But they do open the door to more questions.
Could certain cancers exploit nutrients that otherwise support healthy metabolism? Could a “good” molecule turn “bad” in the wrong environment?
Science continues to evolve, so answers change over time. That’s why this may be a prompt to start asking more questions.
Юлия Сергеева/Adobe Stock
Wait, Isn’t Taurine Supposed to Be Protective?
Here’s where it gets interesting: taurine isn’t new to cancer research. Multiple studies suggest it might inhibit cancer growth in certain contexts. A randomized controlled trial published in the Journal of Cancer Research and Therapeutics highlighted that taurine supplements helped reduce the harmful side effects of chemotherapy in young adults being treated for acute lymphoblastic leukemia. Other studies have shown taurine’s ability to trigger apoptosis (cell death) in various cancer cells, including breast cancer. It also reduces oxidative stress and modulates inflammation, both important factors in cancer prevention.
How can taurine be both cancer-feeder and anticancer? Because biology is context-dependent. Taurine may protect healthy cells and promote recovery in stressed environments. But in the presence of malignant, fast-dividing cells, its same supportive properties could enhance cancer cell survival.
In other words: Is it good or bad? The better question might be, “Good or bad for whom… and under what conditions?”
Is Supplementing Taurine Still Safe?
Taurine has been found to play vital roles in cardiovascular function, brain health, and central nervous system health. Some studies even suggest taurine deficiency may be a driver of aging.
But if you’re undergoing treatment for cancer, especially leukemia, it’s worth asking your oncologist before supplementing.
Continue reading...
